Innovative technologies: Nucleic acid medicines manufacture Rd 2

UK registered organisations can apply for a share of up to £5 million for manufacturing innovation for nucleic acid medicines.

Opportunity Details


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Your project’s total grant funding request must be between £100,000 and £2 million. This can cover up to 70% of costs depending on project type and business size.


Innovate UK

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Innovate UK, part of UK Research and Innovation, will invest up to £5 million to develop and commercialise innovative solutions to improve the resource efficiency, productivity and scalability for the manufacture of nucleic acid medicines in the UK.

Your proposal must show how your project will improve productivity, competitiveness and growth for at least one UK micro, small or medium-sized enterprise (SME) involved in the project.

  • To lead a project your organisation must:

    • be a UK registered business of any size, research organisation, research and technology organisation (RTO), charity, not for profit or public sector organisation
    • collaborate with other UK registered organisations
    • be or work with at least one grant claiming micro, small or medium-sized enterprise (SME)

    If the lead organisation is an RTO it must collaborate with 2 businesses (one SME, and one business of any size).

    A business of any size, research organisation, research and technology organisation (RTO), charity, not for profit or public sector organisation can only lead on one application but can be included as a collaborator in a further 2 applications.

    If a business, research organisation, RTO, charity, not for profit or public sector organisation is not leading any application, it can collaborate in any number of applications.

    An academic organisation can collaborate on any number of applications.

  • Your project must:

    • have a grant funding request between £100,000 and £2 million
    • start by 1 December 2023
    • end by 30 November 2025
    • last between 12 and 24 months
    • carry out all of its project work in the UK
    • intend to exploit the results from or in the UK

    Your project must be focused on the manufacturing of the active nucleic acid medicines, either the ingredients or formulated products. You must be able to demonstrate an improvement in resource efficiency, productivity or throughput as compared with current manufacturing technology, utilising a recognised metric, for example, with process mass intensity.

  • The nucleic acid medicines in scope for this competition include but are not limited to:

    • small activating ribonucleic acid (RNA)
    • messenger ribonucleic acid (mRNA), including self-amplifying mRNA
    • antisense RNA or oligonucleotides
    • small interfering, short interfering or silencing RNA
    • short hairpin RNA
    • micro RNA
    • DNA

    Your project must focus on one or more of the following:

    • in-process monitoring, control and release testing
    • maintenance of product critical quality parameters such as purity, potency and viability
    • novel analytical techniques for product characterisation
    • data acquisition and analysis for nucleic acid medicine manufacturing
    • process challenges for increasing the scale of production,
    • utilisation of alternative solvents for sustainable manufacturing
    • transfer of technology from small-scale manufacturing to a good manufacturing practice (GMP) manufacturing facility
    • lowering of the cost of goods as final output
    • increase in yield of active ingredient
    • increase in speed of production cycle
    • methods to increase the flexibility of established manufacturing facilities include analytical methods
    • innovative workflow to increase productivity and flexibility
    • adaptation of processes from batch to continuous production
  • An online briefing event was held at 3pm on Tuesday 6th June: 2023 click here to watch the recording.

    If you want help to find a project partner, contact Innovate UK KTN’s Medicines Manufacturing team.

Owen Burbidge

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Owen Burbidge

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